Chronic Knee Pain From Osteoarthritis?

You may qualify for a San Diego clinical research study evaluating an investigational single-injection treatment.

Check Your Eligibility

Clinical Expertise

Conducted by experienced research specialists dedicated to advancing treatments for osteoarthritis and chronic pain.

Patient-Focused Research

This study is designed to evaluate a potential new treatment for chronic knee pain caused by osteoarthritis.

Innovative Approach

An investigational single-injection treatment is being studied to help reduce knee pain and improve mobility.

Dedicated Study Support

Our research team will guide you through each step of the study and monitor your progress throughout participation.

Living with chronic knee pain can make everyday moments harder than they should be. Walking, exercising, even getting through a normal day can become a constant reminder of the discomfort caused by osteoarthritis.

A clinical research study in San Diego is exploring a potential new treatment designed to help reduce knee pain and improve quality of life. By participating, you may also help advance research that could lead to better treatment options for others living with this painful condition.

Benefits of Participation

Study Treatment at No Cost: qualified participants will receive the study treatment and related research care at no cost.

Support From an Experienced Research Team: our clinical staff will guide you through each step of the study and monitor your health throughout participation.

Help Advance Osteoarthritis Research: By participating, you may help researchers develop better treatment options for people living with chronic knee pain.

Check Your Eligibility

Eligibility Criteria

Are 40 years of age or older.

Have experienced knee pain from osteoarthritis for more than 6 months.

Still have knee pain despite non-surgical treatments such as medication, physical therapy, or bracing.

May have recent imaging (X-ray, MRI, or CT scan) showing mild to moderate knee osteoarthritis.

Are willing to track your pain and attend study visits for about 6 months.

*Final eligibility will be determined by the study team.

What to Expect

As part of the study, participants may:

Complete a short screening process to determine eligibility for the study.

Track knee pain in a 7-day electronic diary before treatment.

Undergo a diagnostic numbing test of the knee nerves, which helps researchers confirm the source of the pain.

Receive one study treatment and attend follow-up visits over approximately 24 weeks so the research team can monitor progress.

Throughout the study, participants will be supported by the experienced research team at Solaris Research Institute. Study-related care and procedures will be provided at no cost, and participants may be compensated for their time and participation.

The Solaris Leadership Team: Dr. Maja Green & Dr. Krishnan Chakravarthy

Register your Interest

First name Surname Year of birth Email Contact number Zip code Gender

Weight Height

Have you been told by a doctor that you have osteoarthritis (“wear-and-tear arthritis”) in at least one knee?

Yes

Which knee is your main painful knee?

Left

Right

Both equally

Not sure

How long have you had pain in that knee?

Less than 6 months

6 to 12 months

More than 12 months

Over the last 7 days, how severe has your average pain been in that knee?

0 - No Pain

10 - The Worst Pain

Are you still having knee pain after at least 3 months of conservative or non-surgical treatment?

Yes

Which treatments have you tried? *

Acetaminophen / Tylenol

NSAIDs (ibuprofen, naproxen, meloxicam, celecoxib)

Physical therapy

Home exercise program

Knee brace or sleeve

Activity modification

Topical pain medication

Cane, walker, or walking aid

Other

If other, please specify:

Do you have an X-ray, MRI, or CT scan of that knee from the last 6 months?

Yes

If you know, has a doctor described the arthritis as: *

Mild

Moderate

Severe

Not sure

Are you currently taking any medications for knee pain?

Yes

If yes, have those medications and doses been stable for at least 6 weeks?

Yes

I'm not taking medication

Are you currently taking opioid pain medication (tramadol, hydrocodone, oxycodone, hydromorphone)?

Yes

Are you currently taking a GLP-1 medication for diabetes or weight loss? (EG: Ozempic, Wegovy, Mounjaro etc.)

Yes

If yes, how long have you been taking it, and has the dose been stable for at least 6 months?

Yes

I'm not taking a GLP-1

Please list all prescription medications, over-the-counter medicines, and supplements you take regularly. *

Are you taking any of the following? *

Probenecid

Disulfiram

Cimetidine

Gemfibrozil

Teriflunomide

Ribociclib / Kisqali

Quercetin

St. John’s wort

Ginkgo biloba

None / Not sure

Have you had a steroid injection in that knee in the last 3 months? *

Yes

Have you had hyaluronic acid, PRP, stem cell injection, or arthroscopic lavage/debridement in that knee in the last 6 months? *

Yes

Have you had radiofrequency ablation, cryoneurolysis, phenol/alcohol nerve treatment, or another genicular nerve procedure in the last 12 months? *

Yes

Have you ever had genicular artery embolization in that knee? *

Yes

Have you ever had a partial or total knee replacement in that knee? *

Yes

Do you currently have an implanted neurostimulation device for knee pain? *

Yes

Do you have hip, back, or other leg pain that is as bad as or worse than your knee pain? *

Yes

Have you been diagnosed with any inflammatory arthritis? *

Rheumatoid arthritis

Lupus

Psoriatic arthritis

Ankylosing spondylitis

Gout or pseudogout

Other

No / unsure

Have you been diagnosed with fibromyalgia or nerve pain affecting the knee? *

Yes

Do you currently have an infection, fever, or skin infection near the knee? *

Yes

Do you have a bleeding disorder, or take blood thinners that cannot be stopped for a procedure? *

Yes

Have you been told you have serious liver disease or kidney disease? *

Yes

Are you allergic to: *

Contrast dye

Gadolinium

Lidocaine

Phenol

Acetaminophen / Tylenol

No / unsure

Have you had cancer within the last 5 years (excluding treated skin cancer or cervical cancer in situ)? *

Yes

Do you have an immune system disorder or uncontrolled diabetes? *

Yes

Are you involved in a worker’s compensation, disability, or legal claim related to your knee pain? *

Yes

Have you had issues with alcohol or drug abuse within the last year? *

Yes

Are you currently participating in another clinical trial, or have you been in a study in the last 30–90 days? *

Yes

Are you willing to complete a 7-day electronic pain diary before treatment? *

Yes

Are you willing to record your pain daily for up to 24 weeks after treatment? *

Yes

Are you willing to undergo study screening including: questionnaires, lab work, ECG, imaging review, diagnostic numbing block of the knee nerves? *

Yes

Are you able to attend: one treatment visit, a day 3 phone call, and follow-up visits over about 6 months? *

Yes

Are you postmenopausal or permanently unable to become pregnant due to surgery? *

Yes

Male / not applicable

Are you currently pregnant, breastfeeding, or planning to become pregnant during the study? *

Yes

Male / not applicable

Preferred contact method:

How were you informed about our study?

I agree to receive communications from Solaris Research Institute.

I agree

Solaris Research Institute is committed to protecting and respecting your privacy. All the information you provide will be kept confidential and will not be shared or sold to any other organisation without your prior consent. From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you.

A clinical research study for adults living with chronic knee pain from osteoarthritis may be right for you.

If knee pain has been limiting your mobility or affecting your daily life, this research study may offer an opportunity to explore a potential new treatment while helping advance medical research.

Check Your Eligibility